Loading ...

recombinant receptor binding domain protein conjugated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)-maleimide coated cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

Based on

1 Articles
2019 Most recent source

Composition

1

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)-maleimide coated cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

Type Nano Material
Formula
Role core
2

recombinant receptor binding domain protein

Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

No matching record found

Applications

Area Application Nanomaterial Variant Source

vaccine development for middle east respiratory syndrome coronavirus

No matching record found

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source

induction of cellular immune response, subcutaneous

C57BL/6 mouse

codelivery of adjuvant and antigen, subcutaneous

C57BL/6 mouse

induction of antigen-specific CD8+ T cell responses, subcutaneous

C57BL/6 mouse

induction of humoral immune response, subcutaneous

protection against middle east respiratory syndrome coronavirus, subcutaneous

human DPP4-transgenic mouse challenged with middle east respiratory syndrome coronavirus

increase in survival rate of mouse, subcutaneous

codelivery of adjuvant and antigen

No matching record found

Preparation

No matching record found

Method 1

1
  1. mixing
  2. (tris(2-carboxyethyl)phosphine) as reducing agent
Product

recombinant receptor binding domain protein conjugated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)-maleimide coated cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

References

Journal articles

Leon Chien‐Wei Lin; Chen‐Yu Huang; Bing‐Yu Yao; Jung‐Chen Lin; Anurodh Agrawal; Abdullah Algaissi; Bi‐Hung Peng; Yu‐Han Liu; Ping‐Han Huang; Rong‐Huay Juang; Yuan‐Chih Chang; Chien‐Te Tseng; Hui‐Wen Chen; Che‐Ming Jack Hu (2019)
Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

Adv. Funct. Mater., vol. 29, issue 28, pp 1807616 - 1807616


Patents

Sign up for a free trial