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1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)-maleimide coated cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

Based on

1 Articles
2019 Most recent source

Composition

1

cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

Type Nano Material
Formula
Role core
2

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)2000-maleimide

Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source

Details in source

Hydrodynamic size: ~120 nm

Medium/Support: none

View data for this variant only

Details in source

Hydrodynamic size: ~120 nm

Medium/Support: none

View data for this variant only

No matching record found

Characterization

Method Nanomaterial Variant Source

Hydrodynamic size: ~120 nm

Medium/Support: none

View data for this variant only

No matching record found

Preparation

No matching record found

Method 1

Starting materials
  • cyclic diguanylate monophosphate
dissoluttion
1
  1. phosphate buffer pH 7
emulsification
2
  • poly(DL-lactide-co-glycolide)
  1. ice
  2. ultrasonic probe sonicator
  3. 40% amplitude
3
  1. phosphate buffer pH 7
  2. ultrasonic probe sonicator
  3. 30% amplitude
4
  1. pouring
  2. water
  3. 40 °C
  4. stirring
5
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)2000-maleimide
  1. water
solvent evaporation
6
  1. 1 h
filtration
7
  1. 100 kDa MWCO amicon filters
Product

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)-maleimide coated cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

Hydrodynamic size: ~120 nm

Medium/Support: none

View data for this variant only

References

Journal articles

Leon Chien‐Wei Lin; Chen‐Yu Huang; Bing‐Yu Yao; Jung‐Chen Lin; Anurodh Agrawal; Abdullah Algaissi; Bi‐Hung Peng; Yu‐Han Liu; Ping‐Han Huang; Rong‐Huay Juang; Yuan‐Chih Chang; Chien‐Te Tseng; Hui‐Wen Chen; Che‐Ming Jack Hu (2019)
Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

Adv. Funct. Mater., vol. 29, issue 28, pp 1807616 - 1807616


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