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DY677-labeled siLuc loaded methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate) nanoparticles colloid

Based on

1 Articles
2017 Most recent source

Composition

1

methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate) nanoparticles

MeO-PEG-b-PHMEMA NP
Type Nano Material
Formula
Role carriers
2

tumor-targeting and cell-penetrating peptide-amphiphile

TCPA
Type Biomolecule
Formula
Role loaded material
3

DY677-labeled small interfering RNA against luciferase

DY677-labeled siLuc
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
pH stability

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
luciferase-expressing HeLa (Luc-HeLa) cells

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Preparation

Method 1

Type: Physical formation
Source:
  1. Mpph2E
Product

DY677-labeled siLuc loaded methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate) nanoparticles colloid

Hydrodynamic diameter: ~ 30 - ~ 220 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate)
  • tumor-targeting and cell-penetrating peptide-amphiphile
  • DY677-labeled small interfering RNA against luciferase
  1. OgJc4UMdkBhcRFyAFXnXug8XSlOWYWZwtj2Z8F3b
Product

DY677-labeled siLuc loaded methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate) nanoparticles colloid

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate)
  • tumor-targeting and cell-penetrating peptide-amphiphile
  • DY677-labeled small interfering RNA against luciferase
  1. IX5bSLorfhh4Gg7o6AkIVsMUcoTt0HDNcG8VeXd5
Product

DY677-labeled siLuc loaded methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate) nanoparticles colloid

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
  1. lA54jS
Product

DY677-labeled siLuc loaded methoxy-terminated poly(ethylene glycol)-block-poly(2-(hexamethyleneimino)ethyl methacrylate) nanoparticles colloid

Hydrodynamic diameter: ~ 30 - ~ 140 nm

Medium: phosphate buffer solution

Support: none

References

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