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89Zr-labeled PEGylated chelate conjugated mesoporous silica nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

mesoporous silica nanoparticles

MSN
Type Nano Material
Formula
Role core
2

(3-aminopropyl)trimethoxysilane moiety

(3-aminopropyl)trimethoxysilane moiety (3-aminopropyl)triethoxysilane moiety γ-aminopropyltriethoxy silane moiety 3-aminopropyltrimethoxysilane moiety γ-aminopropyltriethoxysilane moiety 3-aminopropyltriethoxysilane moiety (3-aminopropyl)trioxysilane moiety (3-aminopropyl)silanetrioxy group 3-aminopropylsilanetrioxy group 3-aminopropylsiloxy fragment 3-aminopropyl silane moiety 3-aminopropylsilane moiety γ-APTES moiety 3-APTS moiety APTES moiety APTMS moiety AMPS moiety APTS moiety APS moiety
Type Single Compound
Formula -C3H8NO3Si-
Role layer
3

1-(4-isothiocyanatophenyl)- 3-[6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetylhydroxylamino)- 6,11,17,22-tetraazaheptaeicosine] thiourea

1-(4-isothiocyanatophenyl)-3-[6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosine]-thiourea p-isothiocyanatobenzyl-desferrioxamine p-isothiocyanatobenzyldesferrioxamine p-SCN-Bn-deferoxamine p-SCN-Bn-DFO DFO-p-SCN DFO-NCS DFO
Type Single Compound
Formula C33H52N8O8S2
Role layer
4

poly(ethylene glycol) succinate moiety

Type Polymer
Formula
Role layer
5

89zirconium(IV) ion

[89]-zirconium ion zirconium(IV) ion zirconium-89 ion
Type Single Compound
Formula 89Zr4+
Role graft

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Biological effects

Biological system Test details Nanomaterial Variant Source
human prostate carcinoma LNCaP C4-2 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  1. wV4yaoYojcf7vo3aVSIYFzr7eDmC59v0xiz6HHnFJvXsubnh09
Product

89Zr-labeled PEGylated chelate conjugated mesoporous silica nanoparticles

Size: 180 nm

Medium: NaCl solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  1. dpmmkNg3WTUMAuYm1iaF9HLkBZnzbNLiSWTJ
  2. ncQ0Ly
Product

89Zr-labeled PEGylated chelate conjugated mesoporous silica nanoparticles

Size: 180 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  1. 0btH0GhxDipGVLyyOdzsyO7HI0LSjgYL8CZfhlkUrOxOAPERGR
Product

89Zr-labeled PEGylated chelate conjugated mesoporous silica nanoparticles

Size: 180 nm

Medium: Roswell Park Memorial Institute medium 1640

Support: none

References

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