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siRNA-loaded poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(dimethylamino ethyl methacrylate-co-butyl methacrylate) polyplexes

Based on

22 Articles
2017 Most recent source

Composition

1

trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

trastuzumab-conjugated PEG-PEI-MSNP
Type Nano Material
Formula
Role carriers
2

luciferase small interfering RNA

luciferase siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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medicine/veterinary

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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transmission electron microscopy

Biological effects

Biological system Test details Nanomaterial Variant Source
8505C anaplastic thyroid cancer (ATC) tumor-bearing mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. D5g
Product

siRNA-loaded poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(dimethylamino ethyl methacrylate-co-butyl methacrylate) polyplexes

Hydrodynamic diameter: 83.4 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. gID
Product

siRNA-loaded poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(dimethylamino ethyl methacrylate-co-butyl methacrylate) polyplexes

Hydrodynamic diameter: 83.4 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. 8KV
Product

siRNA-loaded poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(dimethylamino ethyl methacrylate-co-butyl methacrylate) polyplexes

Hydrodynamic diameter: 56.6 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. Nxf
Product

siRNA-loaded poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(dimethylamino ethyl methacrylate-co-butyl methacrylate) polyplexes

Hydrodynamic diameter: 83.4 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. VQN
Product

siRNA-loaded poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(dimethylamino ethyl methacrylate-co-butyl methacrylate) polyplexes

Hydrodynamic diameter: 83.4 nm

Medium/Support: none

References

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