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doxorubicin-loaded cross-linked alendronate-poly(ethylene glycol)-hydrazinated hyaluronic acid-hydrazinated poly(aspartic acid) conjugate nanoparticles colloid

Based on

1 Articles
2017 Most recent source

Composition

1

cross-linked hyaluronic acid-hydrazinated poly(aspartic acid) conjugate

(HA-PASP)CL
Type Biomolecule
Formula
Role core
2

hydrazinated alendronate-terminated poly(ethylene glycol)

ALN-PEG-NHNH2
Type Polymer
Formula
Role layer
3

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
alendronate (ALN) release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
CD44 receptor-positive MDA-MB-231 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • doxorubicin hydrogen chloride
  1. CNgM3svABArc0ChIsKpKSYyI6iqZDBH5qID
  2. 1YYTVpmwNzqAP
  3. cDdgY
  4. tNYnJ
  5. 2lb4y57g
Product

doxorubicin-loaded cross-linked alendronate-poly(ethylene glycol)-hydrazinated hyaluronic acid-hydrazinated poly(aspartic acid) conjugate nanoparticles colloid

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

doxorubicin-loaded cross-linked alendronate-poly(ethylene glycol)-hydrazinated hyaluronic acid-hydrazinated poly(aspartic acid) conjugate nanoparticles colloid

Hydrodynamic diameter: 101 - 119 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
  1. oZ3hTI
Product

doxorubicin-loaded cross-linked alendronate-poly(ethylene glycol)-hydrazinated hyaluronic acid-hydrazinated poly(aspartic acid) conjugate nanoparticles colloid

Hydrodynamic diameter: ~ 100 nm

Medium: phosphate buffer solution

Support: none

References

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