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cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Based on

1 Articles
2017 Most recent source

Composition

1

poly(acrylic acid)-b-poly(N-isopropylacrylamide)-b-poly(acrylic acid) triblock polymer

PAA100-b-PNIPAM200-b-PAA100
Type Polymer
Formula
Role carriers
2

cis-dichlorodiammineplatinum(II) moiety

cisplatin moiety CDDP moiety
Type Single Compound
Formula -H6N2Pt-
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
H22 tumor-bearing KM mouse

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Preparation

Method 1

Type: Physical formation
Source:
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 500 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. toZVQjrAPjOKyGCN
  2. S5WjqAhlAwsVSN
  3. sWBp
  4. Odn2UeNY
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 150 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. 9rZiDSJeqgCgSLmV
  2. khyff2s11KvK2C
  3. pZS0
  4. 7WFQ6SKu
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: 999 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. fYb6YQ2ibbgbejiU
  2. XDpiDK0IGMRMxG
  3. b8HQ
  4. d8keYeQb
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 800 nm

Medium: water

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. z2KAUB7BrwfswszS
  2. CJUurw3k5nqPjc
  3. UHX8
  4. XBpBFNsC
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 950 nm

Medium: water

Support: none

References

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