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cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Based on

1 Articles
2017 Most recent source

Composition

1

poly(acrylic acid)-b-poly(N-isopropylacrylamide)-b-poly(acrylic acid) triblock polymer

PAA150-b-PNIPAM200-b-PAA150
Type Polymer
Formula
Role carriers
2

cis-dichlorodiammineplatinum(II) moiety

cisplatin moiety CDDP moiety
Type Single Compound
Formula -H6N2Pt-
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
H22 tumor-bearing KM mouse

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Preparation

Method 1

Type: Physical formation
Source:
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 500 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. U7HDHh4o68xFFKVd
  2. wJpyCk4iHujHio
  3. UZKp
  4. Tb9cwAov
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 150 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. CNCYdr3SEwwKLsPk
  2. oXVASfT1wkLZw0
  3. 3aPQ
  4. tFOqZ4ER
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: 999 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. 7Xc63QN5C3WRoCmz
  2. 9ool4cbBy4Xnta
  3. vLa2
  4. XcypDZ7U
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 800 nm

Medium: water

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. 6wHj4VMIo4NU1caX
  2. xXuBpCDJSutmdp
  3. F37M
  4. tGsYh5W1
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 950 nm

Medium: water

Support: none

References

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