Loading ...

siMDR1/9R-Dox-loaded APTEDB-PEG2000-DSPE/POPC/POPG liposomes

Based on

1 Articles
2017 Most recent source

Composition

1

HEPES-buffered glucose

HBG
Type Complex Compound
Formula
Role core
2

N-maleimide-polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (ammonium salt)/polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (ammonium salt)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)

mal-PEG2000-DSPE/PEG2000-DSPE/POPC/POPG
Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

EDB domain of fibronectin

APTEDB
Type Biomolecule
Formula
Role layer
5

nona-arginine peptide

9R
Type Biomolecule
Formula
Role loaded material
6

siMDR1

Type Biomolecule
Formula
Role loaded material
7

doxorubicin hydrogen chloride

adriblastin hydrochloride doxorubicin hydrochloride adriamycin hydrochloride doxorubicin hydrochoride adriblastin HCl salt adriamycin HCl salt DOX hydrochloride DXR hydrochloride doxorubicin HCl DOX*HCl DOX-HCl DOX·HCl DXR HCl DXR*HCl Dox HCl Dox*HCl DOXS
Type Single Compound
Formula C27H29NO11*HCl
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

More information available to subscribers only.

Or, view sample content

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

More information available to subscribers only.

Or, view sample content

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

More information/entries available to subscribers only.

Or, view sample content

Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c nude mouse xenografted with dox-resistant human breast adenocarcinoma MCF-7/ADR cells

More information/entries available to subscribers only.

Or, view sample content

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • EDB domain of fibronectin/N-maleimide-polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine
  • polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (ammonium salt)
  • [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
See all (5)
  1. fZrD9UWR3YxLKnFs5cf
Product

siMDR1/9R-Dox-loaded APTEDB-PEG2000-DSPE/POPC/POPG liposomes

Hydrodynamic diameter: 102 - 128 nm

Medium/Support: none

References

Full content is available to subscribers only

To view content please choose from the following:

We use cookies to improve your experience with our site. More information

Sign up for a free trial