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DOF-loaded polyalkylated copolymer aggregates

Based on

3 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role core
2

mPEG-b-(AGE-C18)25

Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c mouse with breast cancer 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) triblock copolymer
  • adriblastin
  1. khB13aiLtdrxuGqceXe
  2. w26mffy
  3. R24WtGoN1DnpfexGiaJ
Product

DOF-loaded polyalkylated copolymer aggregates

Diameter: ~ 20 nm

Hydrodynamic diameter: ~ 10 - 50 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  1. aaSrRvi8mTCSFk9NkEhXwHKOt7uYFGgUNlAqblS
  2. uxs
  3. dfTvelc4gO
  4. YsZk4yy7
  5. tMqo7
Product

DOF-loaded polyalkylated copolymer aggregates

Diameter: 137.9 - 239.3 nm

Medium/Support: none

References

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