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polyethylene glycol-conjugated platinum(IV) complex-loaded polyethyleneimine-coated Fe3O4 nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

iron(II,III) oxide

magnetite
Type Single Compound
Formula Fe3O4
Role core
2

poly(iminoethylene)

polyethyleneimine polyaziridine PEI
Type Polymer
Formula
Role layer
3

4-({diamino[(3-carboxypropanoyl)oxy]dichloroplatinio}oxy)-4-oxobutanoic acid

cis,cis,trans-diamminedichlorodisuccinato-platinum(IV) bis((3-carboxypropanoyl)oxidanyl)cisplatin c,c,t-[Pt(NH3)2Cl2(OOCCH2CH2COOH)2] (c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2 dicarboxylic cisplatin(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2 succinic acid-modified cisplatin cis-platinum prodrug disuccinatocisplatin cisplatin prodrug Pt(IV)-(COOH)2 DSCP
Type Single Compound
Formula C8H16Cl2N2O8Pt
Role layer
4

mPEG5k-NH2

Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Fe release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c mouse bearing H22 liver tumor

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Preparation

Method 1

Type: Physical formation
Source:
  1. qrN6TIrz1SMgdXFghNXvJ9jW5KnxwC63qA4Ay13AlSxxsRjQ7OdzJUQvEjIPmFF0bWLV41vkKKLsoherbSs8oBRu9juhEwiVblo9GpvCpUbuCKWlPenvH
  2. boLbuuRtzDO6P6
Product

polyethylene glycol-conjugated platinum(IV) complex-loaded polyethyleneimine-coated Fe3O4 nanoparticles

Diameter: 5.7 nm

Medium/Support: none

References

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