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indocyanine green/tirapazamine-loaded iRGD peptide-conjugated hybrid PLGA/lipid nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

poly(D,L-lactide-co-glycolide)

poly(lactic-co-glycolic acid) PLGA
Type Polymer
Formula
Role core
2

DSPE-mPEG/DPPC/DSPE-PEG-DBCO mixture

Type Complex Compound
Formula
Role layer
3

azido-functionalized iRGD peptide

Type Biomolecule
Formula
Role layer
4

sodium 4-[2-[(1E,3E,5E,7Z)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-2-ylidene]hepta-1,3,5-trienyl]-1,1-dimethylbenzo[e]indol-3-ium-3-yl]butane-1-sulfonate

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Indocyanine Green indocyanine green IC-Green® IGG ICG IcG
Type Single Compound
Formula C43H47N2NaO6S2
Role loaded material
5

tirapazamine

TPZ
Type Single Compound
Formula C7H6N4O2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female Balb/c mouse bearing orthotopic breast 4T1 tumor

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  1. kwSFyOQMvaP3qj
  2. 5DAf134
Product

indocyanine green/tirapazamine-loaded iRGD peptide-conjugated hybrid PLGA/lipid nanoparticles

Diameter: ~ 100 nm

Hydrodynamic diameter: 112.4 nm

Medium/Support: none

References

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