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CPT/DOX-loaded diselenide-rich nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

PEG-b-PBSe diblock copolymer

PEG-b-PBSe
Type Polymer
Formula
Role raw materials
2

(S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione

1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione (S)-(+)-camptothecin camptothecin CPT CMT CP
Type Single Compound
Formula C20H16N2O4
Role loaded material
3

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
CPT release dependent on GSH concentration

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c mouse with mouse mammary tumor EMT-6 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  • (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
  • PEG-b-PBSe diblock copolymer
  1. SfbHVXNKI6xWH9jv
  2. eyXkg7iTS7lVB
Product

CPT/DOX-loaded diselenide-rich nanoparticles

Hydrodynamic diameter: 129 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
  1. HWQx4sgi0PPLITcxW
  2. 0NbvAqnYTYErSXdlKpV88jxL9
Product

CPT/DOX-loaded diselenide-rich nanoparticles

Diameter: ~ 100 nm

Hydrodynamic diameter: 116 nm

Medium/Support: none

References

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