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cyclopamine-encapsulating irinotecan/riboflavin-containing PEG-based polymer nanoparticles colloid

Based on

1 Articles
2016 Most recent source

Composition

1

cyclopamine

CPA CYC CP
Type Single Compound
Formula C27H41NO2
Role core
2

irinotecan-modified polyethyleneglycol-based 4-phenylazobenzoic acid derivative

AZO-C6-PEG-S-Ir polymer
Type Polymer
Formula
Role layer
3

riboflavin-modified polyethyleneglycol-based 4-phenylazobenzoic acid derivative

AZO-C6-PEG-R polymer
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mice bearing with MCF-7 xenograft tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • riboflavin-modified polyethyleneglycol-based 4-phenylazobenzoic acid derivative
  • irinotecan-modified polyethyleneglycol-based 4-phenylazobenzoic acid derivative
  • cyclopamine
  1. wFjsAES6hwtA2mWiJgBj3O7IpGHI2QgpyvpuMhjCRGRsLJszeG45bnMtyeCCuBNmM1v
Product

cyclopamine-encapsulating irinotecan/riboflavin-containing PEG-based polymer nanoparticles colloid

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
Product

cyclopamine-encapsulating irinotecan/riboflavin-containing PEG-based polymer nanoparticles colloid

Hydrodynamic diameter: ~ 40 nm

Medium: Dulbecco's modified Eagle medium containing fetal bovine serum

Support: none

References

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