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firefly luciferase-encoding mRNA loaded PEGylated poly(β-amino esters) nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

mixture of substance based on (poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)/poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)/n = 45/n = 45)

Type Complex Compound
Formula
Role carriers
2

firefly luciferase-encoding mRNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
stability in serum

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • n = 45
  • poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)
  1. 48q8kBe
Product

firefly luciferase-encoding mRNA loaded PEGylated poly(β-amino esters) nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • n = 45
  • poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)
  1. vJdTb9j
Product

firefly luciferase-encoding mRNA loaded PEGylated poly(β-amino esters) nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • n = 45
  • poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)
  1. k78C79n
Product

firefly luciferase-encoding mRNA loaded PEGylated poly(β-amino esters) nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • n = 45
  • poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)
  1. XEwg2pV
Product

firefly luciferase-encoding mRNA loaded PEGylated poly(β-amino esters) nanoparticles

Hydrodynamic diameter: 37.2 - 196.4 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • n = 45
  • poly (1,11-diamino-3,6,9-trioxaundecane/1,11-diamino-3,6,9-trioxaundecane/N-N'-dimethylethylenediamine/N-N'-dimethylethylenediamine/1-aminododecane/1-aminododecane/C27H32O8/C27H32O8)
  1. jYIF2Ex
Product

firefly luciferase-encoding mRNA loaded PEGylated poly(β-amino esters) nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

References

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