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siRNA-loaded iRGD-NP

Based on

13 Articles
2018 Most recent source

Composition

1

bPEG-SS-P123-PEI

PSPP
Type Polymer
Formula
Role carriers
2

siPLK1

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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medicine/veterinary

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
athymic male BALB/c nude mouse bearing human colonic carcinoma HCT-8/T tumor xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. UOL
Product

siRNA-loaded iRGD-NP

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. EPt
Product

siRNA-loaded iRGD-NP

Hydrodynamic diameter: 83.4 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. fZj
Product

siRNA-loaded iRGD-NP

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. XHZ
Product

siRNA-loaded iRGD-NP

Size: not specified

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. 89y
Product

siRNA-loaded iRGD-NP

Size: not specified

Medium/Support: none

References

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