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lopinavir-loaded polymer nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

F127
Type Polymer
Formula
Role core
2

octanoic acid sodium salt

sodium caprylate
Type Single Compound
Formula C8H15NaO2
Role layer
3

[1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide

lopinavir LPV
Type Single Compound
Formula C37H48N4O5
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Biological effects

Biological system Test details Nanomaterial Variant Source
Caco-2 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  • octanoic acid sodium salt
  • poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
  1. l91LBzfO77
  2. kDBXe
Product

lopinavir-loaded polymer nanoparticles

Hydrodynamic diameter: 423 - 459 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  • octanoic acid sodium salt
  • poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
  1. BqHBE5ngYp
  2. fvACZ
Product

lopinavir-loaded polymer nanoparticles

Hydrodynamic diameter: 405 - 437 nm

Medium: water

Support: none

References

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