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lopinavir-loaded polymer nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(vinyl alcohol)

polyvinyl alcohol PVOH PVAI PVA
Type Polymer
Formula
Role core
2

polyoxyethylene (20) sorbitan monolaurate

Polysorbate 20 Alkest TW 20 Tween 20
Type Polymer
Formula
Role layer
3

[1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide

lopinavir LPV
Type Single Compound
Formula C37H48N4O5
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Biological effects

Biological system Test details Nanomaterial Variant Source
Caco-2 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(vinyl alcohol)
  • polyoxyethylene (20) sorbitan monolaurate
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  1. 8pEJpiCvPP
  2. 7DV6A
Product

lopinavir-loaded polymer nanoparticles

Hydrodynamic diameter: 255 - 331 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(vinyl alcohol)
  • polyoxyethylene (20) sorbitan monolaurate
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  1. NOmOJeJ2dD
  2. sFXws
Product

lopinavir-loaded polymer nanoparticles

Hydrodynamic diameter: 540 - 660 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(vinyl alcohol)
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  • polyoxyethylene (20) sorbitan monolaurate
  1. DB4M7ekrVc
  2. XYxnV
Product

lopinavir-loaded polymer nanoparticles

Hydrodynamic diameter: 938 - 1030 nm

Medium: water

Support: none

References

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