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nanovesicles containing PLI/miR-34a complexes

Based on

1 Articles
2016 Most recent source

Composition

1

poly(L-lysine-graft-imidazole)

poly(L-lysine-g-imidazole) PLI
Type Biomolecule
Formula
Role core
2

microRNA

miR
Type Biomolecule
Formula
Role loaded material
3

[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate

1-stearoyl-2- palmitoyl-sn-glycero-3-phosphocholine 1-palmitoyl-2-oleoyl-sn-glycero-3-phos-phocholine 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine palmitoyl-oleoyl-sn-glycero-phosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine palmitoyl oleoyl phosphatidylcholine palmitoyl-oleoyl-phosphatidylcholine palmitoyloleoyl-phosphatidylcholine palmitoyloleoylphosphatidyl choline palmitoyloleoylphosphatidylcholine Zwitterionic phosphatidylcholine L-α-phosphatidylcholine soy phosphatidylcholine phosphatidylcholine phospholipon 90 NG Phospholipon S100 PL S100 Egg-PC soy PC POPC POPS SPC PC EL
Type Single Compound
Formula C42H82NO8P
Role layer
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

DSPE-mPEG
Type Polymer
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c-nude mouse with gastric cancer MKN-74 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
  • cholesterol
  • [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
  1. f5UZg2o70vXcyvsYFn2uc3
  2. k0sIIXAGvhDfUIL
  3. Jo9kIezReUHscxQgxeHFiff7J5v
Product

nanovesicles containing PLI/miR-34a complexes

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
  • cholesterol
  • [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
  1. lmgXoYBBJzVRqBD6FRUxzx
  2. H3GVDnG2D33H8ls
  3. xpwYWW5WPDWybkrRQaVpFq3tiu6
Product

nanovesicles containing PLI/miR-34a complexes

Diameter: ~ 100 - 300 nm

Hydrodynamic diameter: ~ 100 - 300 nm

Medium/Support: none

References

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