Loading ...

spike glycoprotein-laden synthetic virus-like particles

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

gold nanoparticles

Type Nano Material
Formula
Role core
2

IBV spike protein

Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source

Details in source

Details in source

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

No matching record found

Applications

Area Application Nanomaterial Variant Source

vaccination against viral infections synthetic virus-like particles prepared via protein corona formation for vaccination against coronavirus infection

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

No matching record found

Characterization

Method Nanomaterial Variant Source

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

No matching record found

Biological effects

Biological system Test details Nanomaterial Variant Source

immunogenic, intramuscular

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

BALB/c mouse

biodistribution, subcutaneous (sc)

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

immunogenic, intramuscular

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

SPF chicken

protection against viral challenge, intramuscular

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

SPF chicken

reduction of infection-associated symptoms in avian model of coronavirus infection, intramuscular

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

No matching record found

Preparation

No matching record found

Method 1

Type: Physical formation
Starting materials
1
Product

spike glycoprotein-laden synthetic virus-like particles

Method 2

Type: Chemical synthesis
Starting materials
washing
1
  1. water
  2. citrate stabilizer removal
incubation
2
  • IBV spike protein
  1. solution in 10% sucrose
  2. sonication
  3. cooling
centrifugation
3
purification
4
  1. centrifugal washes
  2. 10% sucrose
sonication
5
  1. solution in PBS
Product

spike glycoprotein-laden synthetic virus-like particles

Diameter: 139.2 nm

Medium/Support: none

View data for this variant only

References

Journal articles

Chen, Hui-Wen; Huang, Chen-Yu; Lin, Shu-Yi; Fang, Zih-Syun; Hsu, Chen-Hsuan; Lin, Jung-Chen; Chen, Yuan-I; Yao, Bing-Yu; Hu, Che-Ming J. (2016)
Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection

Biomaterials, vol. 106, pp 111 - 118


Patents

Sign up for a free trial