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IR780/chlorotoxin/lexiscan-loaded poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxyl-L-lysine)/polyethylene glycol nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxyl-L-lysine)

PLGA-PLL
Type Polymer
Formula
Role core
2

near-infrared dye IR780 iodide

IR-780 iodide NIR dye IR780 IR780 iodide IR780 dye IR-780 IR780
Type Single Compound
Formula C36H44ClIN2
Role loaded material
3

2-{4-[(methylamino)carbonyl]-1H-pyrazol-1-yl}adenosine

lexiscan Lexiscan LEX
Type Single Compound
Formula C15H18N8O5
Role loaded material
4

a-malemidyl-u-carboxyl polyethyleneglycol

MAL-PEG-carboxyl
Type Polymer
Formula
Role layer
5

chlorotoxin

CTX
Type Biomolecule
Formula
Role loaded material
6

methoxyl polyethylene glycol thiol

mPEG-SH
Type Polymer
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
male C57BL/6 mouse with induced ischemic stroke

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Nogo-66 receptor antagonist peptide
  • 2-{4-[(methylamino)carbonyl]-1H-pyrazol-1-yl}adenosine
  • near-infrared dye IR780 iodide
  1. XjI9arFVvkvZJqkJRQsvLe3pVtjyufjn5aX
Product

IR780/chlorotoxin/lexiscan-loaded poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxyl-L-lysine)/polyethylene glycol nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

IR780/chlorotoxin/lexiscan-loaded poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxyl-L-lysine)/polyethylene glycol nanoparticles

Hydrodynamic radius: 153.2 nm

Medium: water

Support: none

References

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