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Trastuzumab-targeted Dox-loaded magnetic nanocarriers

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

superparamagnetic iron oxide nanoparticles

iron oxide nanoparticles SPION
Type Nano Material
Formula
Role core
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

thiolated poly(MAA)-PVA graft copolymer

thiolated PVA-PMAA PMASH-modified PVA PMASH-grafted PVA PVA/PMASH PVA-PMASH
Type Polymer
Formula
Role layer
4

Trastuzumab

Tra
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer MDA-MB-231 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Trastuzumab
  1. EjLCrzG00MWOQeQREf4QTFFMx
  2. ahBXsDzgYpmOTGfqsIKxGjb0rkArLCBTByvfOlyWG0VJcFppBolg5OYVM44q2PtRXnxiumXlvSQKrjlOjJ2bUQg
  3. FwS1QCa
  4. dCnLqB3KNc1pQXrR12u4S7SDX9hHXj0B1U0
Product

Trastuzumab-targeted Dox-loaded magnetic nanocarriers

Hydrodynamic diameter: 132.98 - 144.76 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Trastuzumab
  1. 7DinDSAbh84HBCA7zE9x7cdks
  2. j5whKOXyNzwlFJOkVF6XwN1xc9BwUj4ZpObLECUunA6LgIkteoId1XgRJht3BpSfmFPjVmhCk3slDFa7uQ9qNH4
  3. J3Kx6gp
  4. oLGAg5b9WRjTRntkEkcVpccy2yF0tJ1QQUu
Product

Trastuzumab-targeted Dox-loaded magnetic nanocarriers

Hydrodynamic diameter: 450.53 - 463.71 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • Trastuzumab
  1. nhZ4LgnpubMGHDlFBeNLU1D5Z
  2. Sj7aWe06RnscTH7wmalYeiWWbEoD8dMtXaU6kkZXy0h358vF41Tk9AQ6YncwpOJ00oVTGrFBcsr9c94FiRIhw2d
  3. YmEVp6G
  4. RCXuanRrLwqNSGrM0Cxp4GYhgg50GhGoxdr
Product

Trastuzumab-targeted Dox-loaded magnetic nanocarriers

Hydrodynamic diameter: 123.46 - 139.16 nm

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • Trastuzumab
  1. a77HBGbo40cmZy9FtbymZNa7j
  2. 1pCW0Oow6TTP5xnPRJyy0QXtlOCYB6fLHN6OJfVTPfwot99lLAh41Xd6YqxAoOtnMWycvUxN8pYvgN48o62TXyj
  3. CAF3Od5
  4. O7ogJ9HoG4NHh3OKBkUhCnvVeXDv3ET9aT9
Product

Trastuzumab-targeted Dox-loaded magnetic nanocarriers

Hydrodynamic diameter: 118.78 - 131.46 nm

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • Trastuzumab
  1. vmmEpGZsWUhi0ZI6BVZlvEQdK
  2. 6o7QZ1SGqUVw7OWectO4y5AVCi0qwBzSQTHAU6H4XHAbGJNSknkXCsV1rDRYGEKgJPH7Q7hbHuQ4xRmFqixFcQe
  3. 54tNtmm
  4. Y0K02EdhNaZcX7MDtMwYfRIwtRAILZHlKU4
Product

Trastuzumab-targeted Dox-loaded magnetic nanocarriers

Hydrodynamic diameter: 142.22 - 160.46 nm

Medium/Support: none

References

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