Loading ...

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactide)

PEG-b-PLA
Type Polymer
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Dtx Doc
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

More information/entries available to subscribers only.

Or, view sample content

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

More information available to subscribers only.

Or, view sample content

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

More information available to subscribers only.

Or, view sample content

Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c mouse xenografted with highly metastatic human prostate cancer PC3 cells

More information/entries available to subscribers only.

Or, view sample content

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. T6TroroNUUxq28bRKSq1TH
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 307.0 - 352.0 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. KTb0gAECh9pMoomSEVixPK
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 47.5 - 48.7 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. QRHVkIozxNmjdN0w4aBVYb
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 212.2 - 219.4 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. RMxDMVoIaPjwsU456tzbDh
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 212.8 - 226.6 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. I18lR1bmHApBreFqqT98Wn
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 96.6 - 148.4 nm

Medium/Support: none

References

Full content is available to subscribers only

To view content please choose from the following:


Sign up for a free trial