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docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactide)

PEG-b-PLA
Type Polymer
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Dtx Doc
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c mouse xenografted with highly metastatic human prostate cancer PC3 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. D2SWrJIC18FBO0F5yNOupH
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 307.0 - 352.0 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. L32JYKVBbHI3UW30CU1EgA
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 47.5 - 48.7 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. IRhs7EgfhaAYw6Kf33CVEL
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 212.2 - 219.4 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. nkaS8RrvNzYUcFFq4rsP2v
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 212.8 - 226.6 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. YKu0EQJLq0gI47EVwB2rg6
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Hydrodynamic diameter: 96.6 - 148.4 nm

Medium/Support: none

References

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