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drugs-loaded lipid-polymer hybrid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

5-Fu solution

Type Complex Compound
Formula
Role core
2

methoxy poly(ethylene glycol)-poly(lactic acid)

mPEG-PLA
Type Polymer
Formula
Role layer
3

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

irinotecan Camptosa CPT-11 CPT
Type Single Compound
Formula C33H38N4O6
Role loaded material
4

Oxa solution

Type Complex Compound
Formula
Role layer
5

phospholipids mixture

Type Complex Compound
Formula
Role layer
6

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug encapsulation dependent on drug concentration

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
chromatography

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Biological effects

Biological system Test details Nanomaterial Variant Source
healthy female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 5-Fu solution
  • methoxy poly(ethylene glycol)-poly(lactic acid)
  • (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
  1. SDsLcauMQ9dteX8srKa6eyHpdordaKmD3
  2. QOdzx
Product

drugs-loaded lipid-polymer hybrid nanoparticles

Hydrodynamic diameter: ~ 160 nm

Thickness: ~ 15 nm

Medium/Support: none

References

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