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mRNA-loaded lipid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

C12-200/DOPE

Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

C14-PEG 2000
Type Polymer
Formula
Role layer
5

human erythropoietin mRNA

EPO mRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Biological effects

Biological system Test details Nanomaterial Variant Source
female C57BL/6 mice

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. NwjIDZzrfm1YOvh1qe
Product

mRNA-loaded lipid nanoparticles

Size: 98 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. K5HMr5P2Fk6QFkyb96
Product

mRNA-loaded lipid nanoparticles

Size: 111 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. KWOCUF1YwWYluN4hZR
Product

mRNA-loaded lipid nanoparticles

Size: 87 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. dk9ox0OO1Vg6uRb59y
Product

mRNA-loaded lipid nanoparticles

Size: 122 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. o7iRfbsPTnuEwi0zNT
Product

mRNA-loaded lipid nanoparticles

Size: 85 nm

Medium/Support: none

References

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