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mRNA-loaded lipid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

C12-200/DSPC

Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

C14-PEG 2000
Type Polymer
Formula
Role layer
5

human erythropoietin mRNA

EPO mRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Biological effects

Biological system Test details Nanomaterial Variant Source
female C57BL/6 mice

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-distearoyl-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. irTUuLQZYlBs4cPpKJ
Product

mRNA-loaded lipid nanoparticles

Size: 169 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-distearoyl-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. nWtkuZ3Z7vpUNSuc4w
Product

mRNA-loaded lipid nanoparticles

Size: 79 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-distearoyl-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. Vn5jCySeKcZ5Qcia91
Product

mRNA-loaded lipid nanoparticles

Size: 89 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-distearoyl-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. tes836YkYGzmetpzYF
Product

mRNA-loaded lipid nanoparticles

Size: 95 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-distearoyl-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. Iipx2Pr50n3xhueK0D
Product

mRNA-loaded lipid nanoparticles

Size: 64 nm

Medium/Support: none

References

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