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matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Based on

1 Articles
2016 Most recent source

Composition

1

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol network polymer

CS12-MMP-Lys/8-PEG-Gln network polymer
Type Polymer
Formula
Role raw materials
2

water

Type Single Compound
Formula H2O
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
chondroitinase mediated degradation

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Applications

Area Application Nanomaterial Variant Source
implants

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Biological effects

Biological system Test details Nanomaterial Variant Source
bone morphogenetic protein-2 (BMP-2)

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. VYhx8t4o8Wb
  2. XMrqdwhZmhcyGn2rbh3LPLeRerh4fAbexd765
  3. 3NIMNlf5R1DwzaXb0OqrdHYDJQRP
  4. lKWyS
  5. hxUT7Y35MMlKjPW8tNs5G
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 35.8 - 36.6 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. AuQ3alXbp1V
  2. ac06eGEJX7qTYxHhAbjHuHQdMYXKlIBoyBMtm
  3. 9FFXkwJjmR4rGg2zEmkG0xKqZetl
  4. VKqb6
  5. MP4jFbivRuEm7XFMp7BvE
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 39.1 - 39.7 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. OoIFHgfyCjC
  2. XVEpfeLE99UzwKqpEG0xYBiOkk5xWAV2f82Ac
  3. QcyvwvC1SOLxqFGGmH5MqyNm5u61
  4. IEcuW
  5. S5idlYV0wN3loc4izj7ZX
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 18.2 - 20.8 nm

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. h78rssdsB1h
  2. lqtdwMrvc945aA4cT0YRBj8XAaRzhgR6gosMI
  3. E36DpjS642o8KFh7i5fzNm8aMeGm
  4. dX9bs
  5. QuIj4MsOVtmXXjFTT1oTB
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 38.8 - 39.0 nm

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. 18ribfnl5Rm
  2. RkRhAaUHpMtVIlcn4aqsNUcHqmeL70eZSC0XC
  3. uxbbnqKjrSsbxIZI0KAbcSXEAW98
  4. LiLte
  5. HDXYQOF1LS0cfZqC06xkP
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 23.7 - 25.5 nm

Medium/Support: none

References

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