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matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Based on

1 Articles
2016 Most recent source

Composition

1

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol network polymer

CS12-MMP-Lys/8-PEG-Gln network polymer
Type Polymer
Formula
Role raw materials
2

water

Type Single Compound
Formula H2O
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
chondroitinase mediated degradation

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Applications

Area Application Nanomaterial Variant Source
implants

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Biological effects

Biological system Test details Nanomaterial Variant Source
bone morphogenetic protein-2 (BMP-2)

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. fJN2cuPRWU1
  2. QNdeA7X5Z8hegZ0CqjRU1TjAtOLlZg2YKSsO5
  3. 3YTXYCIESIvXAAe7mIUKXXfZG1m4
  4. 9h73z
  5. huimbwoaFsBwv2ZYJZYPF
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 23.7 - 25.5 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. NhlbRTo1Pox
  2. xGqIx18ujv44FsWH8PMqvkWLMwwY4alzk4vOJ
  3. qNFl0fCGCweMgWTqVM0gs48yYGEd
  4. L5cUZ
  5. 9ydb9juGZ39oS96itW0a7
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 35.8 - 36.6 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. sW1sNCK7wPA
  2. hKRFuu2GsLhut1ml5gwzNX6bNSGk7OXidyW2b
  3. Dl9jIhESmSbpWlch07rFfn8a69Ud
  4. wqzWv
  5. ltNWByNEhU4CBa8CiL7kj
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 16.1 - 16.9 nm

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. mVWoY62QNg1
  2. ea3vCuD93wg1PB0dhloNcl4SFBWjqsg0dWvZq
  3. Dagz1ov78gDvwG1OEPEvXe8fpwMi
  4. VhGLL
  5. 5kvHwpRU0mwstyVCpCn9k
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 42.3 - 43.1 nm

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. fjE8jbQPOFv
  2. tCugE3DFSlpkscfQ5zbHK1snJfHFwimYsrxC5
  3. PNiqYdxL4ck95eKGb8oIPimv3L1H
  4. JxWfd
  5. vGmJl3j0glAIwF64LDN3b
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 21.2 - 22.0 nm

Medium/Support: none

References

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