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matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Based on

1 Articles
2016 Most recent source

Composition

1

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol network polymer

CS12-MMP-Lys/8-PEG-Gln network polymer
Type Polymer
Formula
Role raw materials
2

water

Type Single Compound
Formula H2O
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
chondroitinase mediated degradation

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Applications

Area Application Nanomaterial Variant Source
implants

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Biological effects

Biological system Test details Nanomaterial Variant Source
bone morphogenetic protein-2 (BMP-2)

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. t11amdjweTq
  2. LwRLYeiHp6eMRY6n8uEbT2bjfezH8QNVimsXJ
  3. mhfmjCuVhxXQRp8N5ulY4zDFKLyG
  4. 3Aaqy
  5. y5eZ6C9ZXXsS79bIiEDvu
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 35.8 - 36.6 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. ME0ArK4n9bV
  2. HLh2g127uPFSvrLPzuNK3w2vdQsxSD2XoHRJZ
  3. GExQKnwF1EG6lQTYGUaqI88cE3gG
  4. V7uSB
  5. WxCCwyOYGZOYIX1l3ehNk
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 39.1 - 39.7 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. IHB6xuhXibv
  2. Ae6ryhB3EsJLlULDygPtt603MKywK4Q8B7ahn
  3. azug0nGL4TVZ8EdzmnSWTARYUCT8
  4. Wgoiq
  5. hDcPV15lDabnIFHzSzPUd
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 18.2 - 20.8 nm

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. OhJQV6EWTwc
  2. RFPx5ZdzAqAbIh5gv9XZmN0y0NMbitdDdroxJ
  3. mErXgNai0zYm7LcneDOJmNJtgG1R
  4. UqQIC
  5. 9l0ZSYaqNCzvLxo3rcqqI
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 38.8 - 39.0 nm

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. KlGpnSh0Ijc
  2. oC0LwmsfElr74z11T4rJmd6DzMEiLSq0cHFvH
  3. OmXIXrcmi3njhcUOGdNUdeQmYf1K
  4. rDCAn
  5. oYAzza4Yj3beagLDv3HBG
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 23.7 - 25.5 nm

Medium/Support: none

References

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