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GW3965-loaded poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

liver X receptor agonist GW3965 LXR agonist GW3965 GW3965
Type Single Compound
Formula C33H32Cl2F3NO3
Role core
2

poly(D,L-lactide-co-glycolide)-GW3965

PLGA-GW3965
Type Polymer
Formula
Role layer
3

poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)

PLGA43.5K-PEG3.4K-COOH PLGA-PEG-COOH
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
encapsulation efficiency

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
C57BL/6J mouse with zymosan-induced peritonitis

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. 01oEfIKZu0GFE3wpelWdeki
Product

GW3965-loaded poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 124.7 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. kx5EQlo7D4saJ1r2hpaKvNn
Product

GW3965-loaded poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 102 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. 8kKh0VhjQFkryYcOekwImr6
Product

GW3965-loaded poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 122.5 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. uXXI58z8vfcg7CweO0lDcpi
Product

GW3965-loaded poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 87.2 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. QS4Bm3MC8sHvkOtMlV1Qe2C
Product

GW3965-loaded poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 117.1 nm

Medium: water

Support: none

References

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