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GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

liver X receptor agonist GW3965 LXR agonist GW3965 GW3965
Type Single Compound
Formula C33H32Cl2F3NO3
Role core
2

poly(D,L-lactide-co-glycolide)-GW3965

PLGA-GW3965
Type Polymer
Formula
Role layer
3

poly(D,L-lactide)-b-poly(ethylene glycol)

PLA9K-PEG2K PLA-PEG
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
mouse peritoneal macrophages

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. IB2zL5KScO82iO0cbd5kwmz
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 111.3 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. iFoEkyxUPFluhCkqFC7mXcU
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 221.1 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. zhpRildSqgWNyYTZiGcGOPK
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 81.1 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. P77ntEGkWD2nS3lB9cZ5U9R
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 187.8 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. 6TNRHC832GRsCwxU7sFUs0h
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 248.5 nm

Medium: water

Support: none

References

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