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GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

liver X receptor agonist GW3965 LXR agonist GW3965 GW3965
Type Single Compound
Formula C33H32Cl2F3NO3
Role core
2

poly(D,L-lactide-co-glycolide)-GW3965

PLGA-GW3965
Type Polymer
Formula
Role layer
3

poly(D,L-lactide)-b-poly(ethylene glycol)

PLA9K-PEG2K PLA-PEG
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
mouse peritoneal macrophages

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. kSu3JLPiENAHe1sgGMphkqk
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 115.3 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. PKgup3l4M5b6xQkpD3EcIfZ
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 151.1 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. tKY9KkpwZQM44jNV67rxgRZ
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 187.8 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. RUiSxZvAUiFQGwQYcba9xNW
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 248.5 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. bRe4rM0S3oB49zLgVtShlVs
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 111.3 nm

Medium: water

Support: none

References

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