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DTX-loaded PLGA nanoparticles

Based on

4 Articles
2017 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Dtx Doc
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
differential scanning calorimetry

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Biological effects

Biological system Test details Nanomaterial Variant Source
A549 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. 2IxEQhBWQFjsmvKItQN
  2. 2MhjaoTJvRfNoQD5BJtz3zKjXnxfmCOrYTr8OPOdLaPQh0HVH1XRo
Product

DTX-loaded PLGA nanoparticles

Hydrodynamic diameter: 213.1 - 217.3 nm

Length: ~ 320 nm

Width: ~ 80 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. d0eZPyhy6UkTwM
  2. nQeWr78fdbBNXk2Zg8XM
  3. Jb2FYljdgx
Product

DTX-loaded PLGA nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
Product

DTX-loaded PLGA nanoparticles

Diameter: 147.1 - 156.5 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  1. f1nZM80GvfGPoZq
Product

DTX-loaded PLGA nanoparticles

Size: not specified

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
  1. E42up
Product

DTX-loaded PLGA nanoparticles

Size: not specified

Medium/Support: none

References

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