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3-(glycidoxypropyl) triethoxysilane/cystamine/adamantanecarboxylic acid/β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector functionalized hollow silica nanoparticles with 10-hydroxycamptothecin

Based on

1 Articles
2015 Most recent source

Composition

1

hollow silica nanoparticles

Type Nano Material
Formula
Role core
2

3-glycidyloxypropyltrimethoxysilane

3-glycidyloxypropyltrimethoxysilane glycidyloxypropyl triethoxysilane 3-glycidoxypropyltriethoxysilane Dynasylan® GLYEO GLYEO GPTS
Type Single Compound
Formula C12H26O5Si
Role layer
3

2-[(2-aminoethyl)disulfanyl]ethan-1-amine

cystamine CYS CA
Type Single Compound
Formula C4H12N2S2
Role layer
4

adamantanecarboxylic acid

Ad-COOH
Type Single Compound
Formula C11H16O2
Role layer
5

10-hydroxycamptothecin

hydroxycamptothecin 10-HCPT HCPT CPT
Type Single Compound
Formula C20H16N2O5
Role loaded material
6

β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector

CD-PGEA gene vector
Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on glutathione

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  1. 8B7iBdLxLsnT8y3siqGE
  2. WvMdfOEt
  3. J7fG
Product

3-(glycidoxypropyl) triethoxysilane/cystamine/adamantanecarboxylic acid/β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector functionalized hollow silica nanoparticles with 10-hydroxycamptothecin

Hydrodynamic diameter: ~ 200 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  1. vT6EUBpkcDS5Us1VYMgK
  2. JPeOx354
  3. 0O9b
Product

3-(glycidoxypropyl) triethoxysilane/cystamine/adamantanecarboxylic acid/β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector functionalized hollow silica nanoparticles with 10-hydroxycamptothecin

Hydrodynamic diameter: ~ 310 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  1. TZmmBw5ku9SGJAzjrMGg
  2. aTV67qNm
  3. iSLp
Product

3-(glycidoxypropyl) triethoxysilane/cystamine/adamantanecarboxylic acid/β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector functionalized hollow silica nanoparticles with 10-hydroxycamptothecin

Hydrodynamic diameter: ~ 310 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  1. fYGJqtVCllMeqyfjPAFC
  2. i2bxrxC9
  3. A7Gv
Product

3-(glycidoxypropyl) triethoxysilane/cystamine/adamantanecarboxylic acid/β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector functionalized hollow silica nanoparticles with 10-hydroxycamptothecin

Hydrodynamic diameter: ~ 230 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  1. iwfAtI5zFDOsTrxH9elR
  2. Z6CL1rmM
  3. CWab
Product

3-(glycidoxypropyl) triethoxysilane/cystamine/adamantanecarboxylic acid/β-cyclodextrin/ethanolamine-functionalized poly(glycidyl methacrylate) gene vector functionalized hollow silica nanoparticles with 10-hydroxycamptothecin

Hydrodynamic diameter: ~ 270 nm

Medium/Support: none

References

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