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BODIPY-bound Pt(IV) complex-loaded polymer nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

PLGA-BODIPY630/PLGA-b-PEG blend

Type Complex Compound
Formula
Role carriers
2

c,c,t-Pt(NH3)2Cl2-(hexadecylcarbamate)[4-((2-(4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacenyl)ethyl)amino)-4-oxobutanoate]

C16-Pt(IV)-BODIPY
Type Single Compound
Formula C36H63BCl2F2N6O5Pt
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
transmission electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
balb/c mouse injected with murine breast cancer 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  • c,c,t-Pt(NH3)2Cl2-(hexadecylcarbamate)[4-((2-(4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacenyl)ethyl)amino)-4-oxobutanoate]
  • PLGA-BODIPY630
  1. E4e18UNrNePAROyr4pMwFoWddt3WAei5SDP4mwFAZJ5kV
Product

BODIPY-bound Pt(IV) complex-loaded polymer nanoparticles

Diameter: ~ 100 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  • c,c,t-Pt(NH3)2Cl2-(hexadecylcarbamate)[4-((2-(4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacenyl)ethyl)amino)-4-oxobutanoate]
  • PLGA-BODIPY630
  1. 5nAFLE3Oz0b6fjxYifvTLVLk4SrereP0HxyKcUtVmOl39
Product

BODIPY-bound Pt(IV) complex-loaded polymer nanoparticles

Diameter: ~ 100 nm

Medium: water

Support: none

References

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