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7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactic acid)

PEG5K-PLA16K
Type Polymer
Formula
Role carriers
2

1,4,5,8,9-pentamethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl 4-{[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxy}pent-4-enoate

Type Single Compound
Formula C44H52N2O11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HCT-116 colorectal xenograft mouse

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Preparation

Method 1

Type: Physical formation
Source:
Product

7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Hydrodynamic diameter: 39 - 47 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(D,L-lactic acid)
  • 1,4,5,8,9-pentamethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl 4-{[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxy}pent-4-enoate
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Product

7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Size: 18 - 32 nm

Medium/Support: none

References

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