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doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

mPEG-b-(PCL-g-P(DA30-co-DMAEMA20)) micelles mPEG-b-(PCL-g-P(DA-co-DMAEMA)) micelles
Type Nano Material
Formula
Role carriers
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate)
  1. CIsGIrw4kIaKMuqk3azs1KihuzMf
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Hydrodynamic diameter: 125 - 133 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate)
  1. fF05XAcNOhcsvcesRuSQaQoJVMov
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Hydrodynamic diameter: 131 - 143 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate)
  1. ZkmWMW3hoWxEgMI9SP3TUNBPJRAP
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Hydrodynamic diameter: 105 - 125 nm

Medium/Support: none

References

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