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DOX-loaded PNO-modified nanoliposomes

Based on

1 Articles
2014 Most recent source

Composition

1

ammonium sulfate aqueous solution

Type Complex Compound
Formula
Role core
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

(9Z)-9-octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester

(9Z)-9-octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphorylethanolamine 1,2-dioctanoyl-sn-glycero-3-phosphoethanolamine 1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero- 3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleoylphosphatidylethanolamine dioleoyl phosphatidylethanolamine dioleoylphosphatidylethanolamine Lipoid PE 18:1/18:1 DOPE
Type Single Compound
Formula C41H78NO8P
Role layer
4

egg phosphatidylcholine

EPC
Type Complex Compound
Formula
Role loaded material
5

2-((2-(2-monomethoxy-polyethylene glycol-acetamido)ethyl)disulfanyl)ethyl (2-octadecyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)carbamate

PNO
Type Polymer
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on DTT presence

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (9Z)-9-octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
  • egg phosphatidylcholine
  • 2-((2-(2-monomethoxy-polyethylene glycol-acetamido)ethyl)disulfanyl)ethyl (2-octadecyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)carbamate
  1. LSsM0pZDsTIdXWhN8oQkvK5oD3bNLrRu
  2. 02gZDIiWFM5z00Pg9cHZetT0Vma4rI0Fy
  3. dOdmpqYrIn2MkileyDv
  4. qldoEmZzyBoaFEp7xcNJJ
Product

DOX-loaded PNO-modified nanoliposomes

Hydrodynamic diameter: 167 - 185 nm

Medium/Support: none

References

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