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doxorubicin-loaded hybrid polymeric micelles

Based on

1 Articles
2014 Most recent source

Composition

1

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role core
2

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-b-poly(ethylene glycol)2k

DSPE-b-PEG2k
Type Polymer
Formula
Role layer
3

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-b-PEG3.5k-Tatp

DSPE-b-PEG3.5k-Tatp
Type Polymer
Formula
Role loaded material
4

poly(L-glutamic acid)5.6k-b-poly(D,L-lactic acid)1.8k

PGA5.6k-b-PLA1.8k
Type Polymer
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on micelle composition

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c mouse with human melanoma A375 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  1. zkN
  2. 13BawUcV
Product

doxorubicin-loaded hybrid polymeric micelles

Hydrodynamic diameter: 93.28 - 96.72 nm

Medium/Support: none

References

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