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PTX-loaded PLPC/siRNA nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

chondroitin sulfate/protamine-complexed anti-VEGF siRNA

chondroitin sulfate/protamine-complexed siVEGF
Type Biomolecule
Formula
Role core
2

mixture of substance based on (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol)2000]/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol)2000]/(2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid/(2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid/N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium/N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium)

Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

Paclitaxel

Plaxicel Abraxane Paxene Taxol PCL PAC PTX PX
Type Single Compound
Formula C47H51NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mouse bearing human breast MCF-7 cancer

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
See all (4)
Product

PTX-loaded PLPC/siRNA nanoparticles

Hydrodynamic diameter: 122.94 - 126.90 nm

Medium/Support: none

References

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