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sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

D-α-tocopheryl polyethylene glycol 1000 succinate

TPGS
Type Polymer
Formula
Role layer
3

dioleoylphosphatidic acid

dioleoylphosphatydic acid DOPA
Type Single Compound
Formula C39H73O8P
Role layer
4

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

sorafenib SFN SOR SF
Type Single Compound
Formula C21H16ClF3N4O3
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Biological effects

Biological system Test details Nanomaterial Variant Source
C3H/HeNCrNarl mouse bearing HCA-1 tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • D-α-tocopheryl polyethylene glycol 1000 succinate
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • dioleoylphosphatidic acid
See all (4)
  1. J1i3
Product

sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: ~ 187 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • dioleoylphosphatidic acid
  • D-α-tocopheryl polyethylene glycol 1000 succinate
See all (4)
  1. Y8Yx
Product

sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: ~ 155 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Product

sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: ~ 187 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • D-α-tocopheryl polyethylene glycol 1000 succinate
  • dioleoylphosphatidic acid
See all (4)
  1. houJ
Product

sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: ~ 118 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Product

sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: ~ 155 nm

Medium: water

Support: none

References

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