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camptothecin-loaded PEG-P(Lys(DP)) micelles

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

PEG-P(Lys(DP))

Type Polymer
Formula
Role raw materials
2

(S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione

1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione (S)-(+)-camptothecin camptothecin CPT CMT CP
Type Single Compound
Formula C20H16N2O4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
balb/c nu/nu mice with subcutaneous AY27 xenografts

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • PEG-P(Lys(DP))
  • (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
  1. EWPe6cNchQBrAmhy7TFnANmIVc3xgmPIChpWgfxyLboBsC3FS8JDH
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Product

camptothecin-loaded PEG-P(Lys(DP)) micelles

Hydrodynamic diameter: 45 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • PEG-P(Lys(DP))
  • (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
  1. iplXuHcGUgLgfwmmG4hhX518ivKSmv5Ng087hJggNBVaLNB8Zxke6
  2. EKUaBGaKPNmGM6dXczPzA3HSe0KigF
  3. UZs
  4. DkE1eIQ1fI
  5. FzNQ
Product

camptothecin-loaded PEG-P(Lys(DP)) micelles

Hydrodynamic diameter: 44 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • PEG-P(Lys(DP))
  • (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
  1. yF4AvDgtqyIWlr8d7NgX9toXke2WAmhYvbTwTSnGDHf9RcnWGCKLC
  2. Q4bgzjVoPxXEts7i0roRiICI6hg8t8
  3. hDY
  4. kNU3943Eg9
  5. cxwu
Product

camptothecin-loaded PEG-P(Lys(DP)) micelles

Hydrodynamic diameter: 43 nm

Medium: water

Support: none

References

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