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loperamide hydrochloride-loaded carbosilane cationic dendrons of second generation-functionalized poly-(lactic-co-glycolic) acid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

carbosilane cationic dendrons of second generation

dendron G2SN
Type Complex Compound
Formula
Role layer
3

4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride

loperamide hydrochloride
Type Single Compound
Formula C29H34Cl2N2O2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human blood

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride
  • poly(lactic-co-glycolic acid)
  1. M4PxLLZKJdm4D
  2. PUhIINjKuY6cy1INp37LUplTR
  3. CgjyfiRByJQIkeJbhzpsMozw43qO
Product

loperamide hydrochloride-loaded carbosilane cationic dendrons of second generation-functionalized poly-(lactic-co-glycolic) acid nanoparticles

Hydrodynamic radius: 97 - 99 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride
  • poly(lactic-co-glycolic acid)
  1. puEYVfzv44Pi9
  2. OKKlxqdiv6zeM1rRSgBH5izpF
  3. tFuLfnmsWcPtcBEsMhA6PLJdHGW0
Product

loperamide hydrochloride-loaded carbosilane cationic dendrons of second generation-functionalized poly-(lactic-co-glycolic) acid nanoparticles

Hydrodynamic radius: 717 - 803 nm

Medium: veronal buffered saline/human serum albumin

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride
  • poly(lactic-co-glycolic acid)
  1. j5gGKmHC3I7Iq
  2. DZ05SkL7Ax81DdOB7Nmhurk4a
  3. 4YWMt1U1VW4Ltkhy3djNGLVSeeaB
Product

loperamide hydrochloride-loaded carbosilane cationic dendrons of second generation-functionalized poly-(lactic-co-glycolic) acid nanoparticles

Hydrodynamic radius: 64 - 74 nm

Medium: veronal buffered saline

Support: none

References

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