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1.8 % cholesteryl BODIPY FL C12/0.2 % cholesteryl BODIPY 542/563 C11-labeled squalenoyladenosine nanoassemblies

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1 Articles
2015 Most recent source

Composition

1

squalenoyladenosine

SQAd
Type Single Compound
Formula C39H59N5O3
Role carriers
2

4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid cholesterol ester

cholesteryl BODIPY® FL C12
Type Single Compound
Formula C50H77BF2N2O2
Role loaded material
3

cholesteryl 4,4-difluoro-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoate

cholesteryl BODIPY® 542/563 C11
Type Single Compound
Formula C54H77BF2N2O3
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
förster resonance energy transfer

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human cerebral endothelial CMEC/D3 cell monolayer

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • squalenoyladenosine
  • 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid cholesterol ester
  • cholesteryl 4,4-difluoro-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoate
  1. 3MuPY0dbBUDI59AB1OXME0
Product

1.8 % cholesteryl BODIPY FL C12/0.2 % cholesteryl BODIPY 542/563 C11-labeled squalenoyladenosine nanoassemblies

Hydrodynamic diameter: ~ 136 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • squalenoyladenosine
  • 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid cholesterol ester
  • cholesteryl 4,4-difluoro-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoate
  1. OeLxFFSSS5sEQ11KFrNJqi
Product

1.8 % cholesteryl BODIPY FL C12/0.2 % cholesteryl BODIPY 542/563 C11-labeled squalenoyladenosine nanoassemblies

Hydrodynamic diameter: ~ 121 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • squalenoyladenosine
  • 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid cholesterol ester
  • cholesteryl 4,4-difluoro-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoate
  1. YIdtOQR31fb1xNUx94s16f
Product

1.8 % cholesteryl BODIPY FL C12/0.2 % cholesteryl BODIPY 542/563 C11-labeled squalenoyladenosine nanoassemblies

Hydrodynamic diameter: ~ 122 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • squalenoyladenosine
  • 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid cholesterol ester
  • cholesteryl 4,4-difluoro-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoate
  1. qTmFkSU28qMEqhdc8XymbK
Product

1.8 % cholesteryl BODIPY FL C12/0.2 % cholesteryl BODIPY 542/563 C11-labeled squalenoyladenosine nanoassemblies

Hydrodynamic diameter: ~ 133 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • squalenoyladenosine
  • 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid cholesterol ester
  • cholesteryl 4,4-difluoro-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoate
  1. Gq7xuzLnLQWOTf6pXiL0yT
Product

1.8 % cholesteryl BODIPY FL C12/0.2 % cholesteryl BODIPY 542/563 C11-labeled squalenoyladenosine nanoassemblies

Hydrodynamic diameter: ~ 119 nm

Medium: water

Support: none

References

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