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docetaxel-poly(lactic-co-glycolic acid)/polyethyleneimine/tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin/hyaluronan nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material
3

poly(iminoethylene)

polyethyleneimine polyaziridine PEI
Type Polymer
Formula
Role layer
4

sodium 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin

tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin TPPS4
Type Single Compound
Formula C44H26N4Na4O12S4
Role loaded material
5

hyaluronan

HA
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
docetaxel release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
fluorescence spectroscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer MDA-MB-231 cells

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Preparation

Method 1

Type: Physical formation
Source:
  1. L69nzol2vRmTgWZViL5oZ4TCDtL
  2. 08IT
Product

docetaxel-poly(lactic-co-glycolic acid)/polyethyleneimine/tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin/hyaluronan nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Product

docetaxel-poly(lactic-co-glycolic acid)/polyethyleneimine/tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin/hyaluronan nanoparticles

Hydrodynamic diameter: 188 - 300 nm

Medium: Dulbecco's modified Eagle medium

Support: none

Method 3

Type: Physical formation
Source:
Product

docetaxel-poly(lactic-co-glycolic acid)/polyethyleneimine/tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin/hyaluronan nanoparticles

Hydrodynamic diameter: ~ 172 - 223 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Product

docetaxel-poly(lactic-co-glycolic acid)/polyethyleneimine/tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin/hyaluronan nanoparticles

Hydrodynamic diameter: ~ 230 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Product

docetaxel-poly(lactic-co-glycolic acid)/polyethyleneimine/tetrasodium meso-tetra(4-sulfonatophenyl)porphyrin/hyaluronan nanoparticles

Hydrodynamic diameter: ~ 150 nm

Medium: water

Support: none

References

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