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PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

mesoporous silica nanoparticles

MSNPs
Type Nano Material
Formula
Role core
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2'-deoxy-2',2'-difluorocytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material
3

DPPC/cholesteroll/DSPE-PEG

Type Complex Compound
Formula
Role layer
4

Paclitaxel

Plaxicel Abraxane Paxene Taxol PAC PCL PTX PX
Type Single Compound
Formula C47H51NO14
Role partial layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
GEM release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Biological effects

Biological system Test details Nanomaterial Variant Source
athymic BALB/c nu/nu female mouse with orthotopic pancreatic PANC-1 tumor xenograft

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. yQl
  2. gRh3
  3. a6RR6D8
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. Pon
  2. YmxE
  3. 5dNQg6g
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. trz
  2. vAyW
  3. UUgs8Xk
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Hydrodynamic particle size: 112 nm

Thickness: 7 nm

Medium: saline/serum mixture

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. VdG
  2. dVFd
  3. ZmBthzP
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Hydrodynamic particle size: ~ 101 nm

Medium: saline

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. ZMU
  2. 06NS
  3. 1TA8yao
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Size: not specified

Medium/Support: none

References

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