Loading ...

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

hyaluronic acid-cystamine-polylactic-co-glycolic acid

HA-SS-PLGA polymer HA-SS-PLGA
Type Polymer
Formula
Role carriers
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

cyclopamine

CPA CYC CP
Type Single Compound
Formula C27H41NO2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
cyclopamine release dependent on redox environment

More information/entries available to subscribers only.

Or, view sample content

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

More information available to subscribers only.

Or, view sample content

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

More information/entries available to subscribers only.

Or, view sample content

Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer cell lines MCF-7

More information/entries available to subscribers only.

Or, view sample content

Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • hyaluronic acid-cystamine-polylactic-co-glycolic acid
  • cyclopamine
  1. GedF54J6Atrel1Kt6nNCuqfASX
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: 268.9 - 297.3 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • hyaluronic acid-cystamine-polylactic-co-glycolic acid
  • cyclopamine
  1. ad3XdZnuDvXjTbpoawM78LAnVN
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: 233.1 - 257.5 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: ~ 200 - ~ 400 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Size: ~ 200 - ~ 300 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
  1. DrNASZPXqq9k
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: 401 nm

Medium: phosphate buffer solution

Support: none

References

Full content is available to subscribers only

To view content please choose from the following:


Sign up for a free trial