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gemcitabine-DNA-encapsulated EPL-modified co-polymer nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

methylated polyethylene glycol-b-poly lactic-glycolic acid

mPEG-PLGA
Type Polymer
Formula
Role core
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2'-deoxy-2',2'-difluorocytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material
3

ε-polylysine

EPL
Type Biomolecule
Formula
Role layer
4

deoxyribonucleic acid

DNA
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
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Product

gemcitabine-DNA-encapsulated EPL-modified co-polymer nanoparticles

Size: 50 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
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Product

gemcitabine-DNA-encapsulated EPL-modified co-polymer nanoparticles

Size: not specified

Medium: fetal bovine serum

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
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  2. 24GbH
  3. M10ZmNaCNh
Product

gemcitabine-DNA-encapsulated EPL-modified co-polymer nanoparticles

Hydrodynamic diameter: 122.9 nm

Medium: water

Support: none

References

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