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gemcitabine-DNA-loaded lipid-polymer hybrid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

methylated polyethylene glycol-b-poly lactic-glycolic acid

mPEG-PLGA
Type Polymer
Formula
Role core
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2'-deoxy-2',2'-difluorocytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material
3

ε-polylysine

EPL
Type Biomolecule
Formula
Role layer
4

deoxyribonucleic acid

DNA
Type Biomolecule
Formula
Role layer
5

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(PEG)2000]

DSPE-PEG-2000
Type Polymer
Formula
Role layer
6

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
DNA release

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
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Product

gemcitabine-DNA-loaded lipid-polymer hybrid nanoparticles

Size: 60 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
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  3. zmsQBuBYOQ
Product

gemcitabine-DNA-loaded lipid-polymer hybrid nanoparticles

Size: not specified

Medium: fetal bovine serum

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
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  3. W60bIW0gU8
Product

gemcitabine-DNA-loaded lipid-polymer hybrid nanoparticles

Hydrodynamic diameter: 141.8 nm

Medium: water

Support: none

References

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